Bone Architecture and Glucose Metabolism in Men With Prostate Cancer

Grant number: 1062073 | Funding period: 2014 - 2018

Completed

Abstract

Androgen deprivation therapy (ADT) is a type of hormonal treatment which is effective for prostate cancer treatment. However, ADT may cause bone fragility, weight gain, diabetes and heart disease. We will examine the effects of a bone strengthening treatment on bone structure and glucose metabolism in men receiving ADT. This trial should help in better define the risk benefit ratio of ADT, and therefore provide treating doctors with better guidance as to when and how to use this therapy.

Related publications (5)

Scholarly works icon

Zoledronic acid does not affect insulin resistance in men receiving androgen deprivation therapy: a prespecified secondary analysis of a randomised controlled trial

AS Cheung, R Hoermann, J Zhu, D Lim Joon, JD Zajac, M Grossmann

2021-01-01

Background: Animal studies suggest that undercarboxylated osteocalcin may improve insulin sensitivity via its effect on testicular..

Scholarly works icon

Differing Effects of Zoledronic Acid on Bone Microarchitecture and Bone Mineral Density in Men Receiving Androgen Deprivation Therapy: A Randomized Controlled Trial

AS Cheung, R Hoermann, A Ghasem-Zadeh, AJ Tinson, V Ly, SV Milevski, DL Joon, JD Zajac, E Seeman, M Grossmann

2020-10-01

Androgen deprivation therapy (ADT) given to men with prostate cancer causes rapid and severe sex steroid deficiency, leading to in..

Scholarly works icon

Estradiol as a male hormone

N Russell, M Grossmann

2019-01-01

Evidence has been accumulating that, in men, some of the biological actions traditionally attributed to testosterone acting via th..

Scholarly works icon

Reproductive endocrinology of nonalcoholic fatty liver disease

M Grossmann, ME Wierman, P Angus, DJ Handelsman

2019-01-01

The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex steroid signaling influences hepatic e..

Scholarly works icon

Testosterone treatment in older men: clinical implications and unresolved questions from the Testosterone Trials

BB Yeap, ST Page, M Grossmann

2018-08-01

A decrease in the concentration of circulating testosterone in many older men is a biomarker and possibly a rectifiable contributi..

University of Melbourne Researchers